J. Wesson Ashford, MD, Ph.D. A major goal will be to determine whether treatment with leptin reduced the levels of a protein called tau, which is elevated in the cerebrospinal fluid of Alzheimer patients. Replacement therapy in leptin continued .High levels of the hormone leptin regulation of energy was associated with low rates of disease in a study published in TheJournal of the American Medical Association.
Leptin has been shown to reduce the levels of B-amyloid, the main constituent of the deposits, or plaques, that occur in the brain of people suffering from Alzheimer?s disease.
If our results are confirmed by others, leptin levels in older adults may serve as one of many possible biomarker for healthy aging and the brain, especially, may open new avenues in order to possible preventive and therapeutic interventions, write the researchers. Leptin replacement therapy
But Seshadri said it remains to be seen whether leptin replacement therapy would benefit humans with Alzheimer?s or help protect against disease.
He said the study reinforces the growing awareness that the health problems associated with procedures such as obesity and resistance increase the risk of dementia in old age.
Tau protein is a key that allows the transport along the fibers of the brain, he tells WebMD. If leptin decreases the levels of tau protein in cerebrospinal fluid, which tells us something is happening. So we only need 45 patients to demonstrate an effect.
Over 12 years of follow-up, those with lower levels of leptin were about four times more likely to develop Alzheimer?s than those with the highest levels.
Ashford is with the Center Stanford / VA Aging Clinical Research, Stanford, California
The treatment with leptin has been shown in studies on animals recent to improve the performance of the memory, even after the onset of Alzheimer?s disease, such as dementia.
Discovered in the mid-1990, leptin is produced by fat cells and is considered critical for the regulation and. But there is evidence suggesting a role more and more of the hormone in brain development and memory.
Higher concentrations at the beginning of leptin were associated with lower rates of dementia years later. This association was observed even after adjusting for the impact of quarantine abdominal or belly fat, which was recently identified as a risk factor for Alzheimer?s disease early.
The study initially included 785 elderly participants in the Framingham Heart Study in progress, which began enrolling patients in 1948.
The National Institutes of Health recently awarded nearly $ 3 million for a small pilot study of leptin replacement therapy in patients with Alzheimer?s disease.
?Our skeleton with its bones, joints and muscle connections serves us so well in our daily lives that we hardly pay attention to this great system,? said Dr. Elazar Zelzer Department of Molecular Genetics at the Weizmann Institute. ?While previous research has uncovered the mechanisms that contribute to the development and growth of each component of this complex organ and wonderfully adaptable, specific interactions between bones, muscles and tendons that drive the entire musculoskeletal system are not fully understood.
Our study raises a strong possibility that leptin may actually play a role in various pathological processes that cause Alzheimer?s disease clinic, the researcher Sudha Seshadri, MD, of Boston University School of Medicine, tells WebMD. The measurement of levels of leptin
If confirmed, the researchers say the findings could have important implications in the search for effective therapies to prevent and treat disease.
Source: http://www.exercise24.org/?p=514
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